UKMLA Revision
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Sexual Health2 UKMLA questions

Syphilis — UKMLA Revision Notes

Syphilis is an important clinical condition in Sexual Health that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Syphilis as outlined in current NICE guidelines.

Key Facts

  • Syphilis is a key condition on the GMC UKMLA Content Map
  • Commonly tested in the Sexual Health section of the UKMLA Applied Knowledge Test
  • Understand the pathophysiology, clinical features, investigations, and management
  • NICE guidelines provide the evidence base for management decisions
  • Consider differential diagnoses and red flag symptoms in clinical scenarios

Investigations

  • STI screen (GC/Chlamydia NAAT)
  • HIV test
  • Syphilis serology
  • Hepatitis B/C serology
  • Urine/swab MC&S
  • Pelvic USS

Management

  • Partner notification and treatment
  • STI treatment per BASHH guidelines
  • HIV post-exposure prophylaxis (PEP) if indicated
  • Contraception counselling
  • Sexual health outpatient follow-up
  • Safeguarding if under 16

Practice 2+ Syphilis Questions

Test your knowledge with SBA questions on Syphilis and all 430 UKMLA Content Map conditions. Instant feedback, NICE guideline explanations, and spaced repetition included.