UKMLA Revision
Home/UKMLA Revision/Sjögren's syndrome
Musculoskeletal4 UKMLA questions

Sjögren's syndrome — UKMLA Revision Notes

Sjögren's syndrome is an important clinical condition in Musculoskeletal that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Sjögren's syndrome as outlined in current NICE guidelines.

Key Facts

  • Sjögren's syndrome is a key condition on the GMC UKMLA Content Map
  • Commonly tested in the Musculoskeletal section of the UKMLA Applied Knowledge Test
  • Understand the pathophysiology, clinical features, investigations, and management
  • NICE guidelines provide the evidence base for management decisions
  • Consider differential diagnoses and red flag symptoms in clinical scenarios

Investigations

  • X-ray of affected joint
  • FBC, CRP, ESR
  • Rheumatoid factor, anti-CCP
  • ANA, dsDNA
  • Joint aspiration
  • MRI joint

Management

  • Analgesia (paracetamol, NSAIDs)
  • Physiotherapy and exercise
  • DMARDs (methotrexate, hydroxychloroquine) for inflammatory arthritis
  • Biologics (anti-TNF) if refractory
  • Rheumatology outpatient follow-up
  • Orthopaedic referral if surgical intervention needed

Practice 4+ Sjögren's syndrome Questions

Test your knowledge with SBA questions on Sjögren's syndrome and all 430 UKMLA Content Map conditions. Instant feedback, NICE guideline explanations, and spaced repetition included.