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Sick sinus syndrome — UKMLA Revision Notes

Sick sinus syndrome is an important clinical condition in Cardiology that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Sick sinus syndrome as outlined in current NICE guidelines.

Key Facts

  • Sick sinus syndrome is a key condition on the GMC UKMLA Content Map
  • Commonly tested in the Cardiology section of the UKMLA Applied Knowledge Test
  • Understand the pathophysiology, clinical features, investigations, and management
  • NICE guidelines provide the evidence base for management decisions
  • Consider differential diagnoses and red flag symptoms in clinical scenarios

Investigations

  • 12-lead ECG
  • Echocardiogram
  • Troponin I/T
  • FBC, U&E, LFTs
  • BNP/NT-proBNP
  • Chest X-ray

Management

  • Optimise cardiovascular risk factors (BP, lipids, diabetes)
  • Antiplatelet/anticoagulation as indicated
  • Beta-blocker, ACE inhibitor, statin
  • Cardiology outpatient follow-up
  • Patient education and lifestyle advice
  • Device therapy (ICD/pacemaker) if indicated

Practice 5+ Sick sinus syndrome Questions

Test your knowledge with SBA questions on Sick sinus syndrome and all 430 UKMLA Content Map conditions. Instant feedback, NICE guideline explanations, and spaced repetition included.