Hypercalcaemia of malignancy — UKMLA Revision Notes

Hypercalcaemia of malignancy is an important clinical condition in Endocrinology that is tested in the UKMLA Applied Knowledge Test (AKT). Medical students and doctors preparing for the UKMLA or PLAB 1 must understand the pathophysiology, clinical presentation, investigations, and evidence-based management of Hypercalcaemia of malignancy as outlined in current NICE guidelines.

Key Facts

Hypercalcaemia of malignancy is a key condition on the GMC UKMLA Content Map
Commonly tested in the Endocrinology section of the UKMLA Applied Knowledge Test
Understand the pathophysiology, clinical features, investigations, and management
NICE guidelines provide the evidence base for management decisions
Consider differential diagnoses and red flag symptoms in clinical scenarios

Investigations

TFTs (TSH, T4, T3)
Fasting glucose/HbA1c
Cortisol (9am)
Pituitary MRI
Bone profile
Urine/serum osmolality

Management

Hormone replacement/suppression as indicated
Lifestyle modification (diet, exercise)
Monitor for complications
Endocrinology outpatient follow-up
Patient education and self-monitoring
Surgical referral if indicated

Practice 3+ Hypercalcaemia of malignancy Questions

Test your knowledge with SBA questions on Hypercalcaemia of malignancy and all 430 UKMLA Content Map conditions. Instant feedback, NICE guideline explanations, and spaced repetition included.